Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PIM2 | Q9P1W9 | 14/20 | 0.43 |
| ▸ | PIM1 | P11309 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6683041 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPIM2 | |
| SCHEMBL6681005 | 0.83 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPIM2 | |
| SCHEMBL6587943 | 0.74 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6688261 | 0.73 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DTHRB | |
| SCHEMBL28500089 | 0.69 | FOS (0.61) | THRBHTTCYP1A1CYP1A2CYP2D6 | |
| SCHEMBL27684130 | 0.68 | THRB (0.64) | PIM2THRBHTTCYP1B1ATM | |
| SCHEMBL28498982 | 0.68 | THRB (0.64) | PIM2THRBHTTCYP1B1ATM | |
| SCHEMBL4699816 | 0.67 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCSNK2A2 | |
| SCHEMBL6685741 | 0.67 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL80786 | 0.66 | FOS (0.72) | THRBCYP1A1CYP1A2CYP2D6CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056798-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2004-07-08 | — | — | WO | claimed |
| WO-2004056798-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2004-07-08 | — | — | WO | disclosed |