SCHEMBL6588154

SCHEMBL6588154

CCOC(=O)N1c2cc(OC)c(OC)cc2C(N(Cc2ccccc2)C(=O)Cc2cccc(Br)c2)CC1C

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PTGDR2 Q9Y5Y4 4/20 0.41
POLB P06746 2/20 0.38
CETP P11597 2/20 0.37
CHRM2 P08172 2/20 0.36
CHRM1 P11229 2/20 0.36
CHRM3 P20309 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
ALDH1A1 P00352 2/20 0.35
LMNA P02545 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
BCHE P06276 2/20 0.35
ACHE P22303 2/20 0.35
ABCB1 P08183 1/20 0.34
KDM4E B2RXH2 1/20 0.34
CTSD P07339 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6588142 1.00 PTGDR2 (0.41) PTGDR2POLBCETPCHRM2CHRM1
SCHEMBL6588150 1.00 PTGDR2 (0.41) PTGDR2POLBCETPCHRM2CHRM1
SCHEMBL6588534 0.90 PTGDR2 (0.41) PTGDR2CETPNPSR1ALDH1A1LMNA
SCHEMBL6588540 0.90 PTGDR2 (0.41) PTGDR2CETPNPSR1ALDH1A1LMNA
SCHEMBL6588537 0.90 PTGDR2 (0.41) PTGDR2CETPNPSR1ALDH1A1LMNA
SCHEMBL6588174 0.88 CETP (0.49) PTGDR2CETPKDM4E
SCHEMBL6589210 0.88 HTR1A (0.41) PTGDR2ALDH1A1LMNAACHE
SCHEMBL6588180 0.88 CETP (0.49) PTGDR2CETPKDM4E
SCHEMBL6589204 0.88 HTR1A (0.41) PTGDR2ALDH1A1LMNAACHE
SCHEMBL6588183 0.88 CETP (0.49) PTGDR2CETPKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1114032-B1 4-AMINO SUBSTITUTED-2-SUBSTITUTED-1,2,3,4-TETRAHYDROQUINOLINES AS CETP INHIBITORS PFIZER PROD INC (US) 2004-06-02 EP disclosed
US-6489478-B1 CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH INHIBITORS AND THE USE OF SUCH INHIBITORS TO ELEVATE CERTAIN PLASMA LIPID LEVELS, INCLUDING HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER CERTAIN PFIZER INC. 2002-12-03 US disclosed
US-6140343-A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS WHICH ARE USED TO ELEVATE HIGHDENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER LOW DENSITY LIPOPROTEIN-CHOLESTEROL AND TRIGLYCERIDES; FOR TREATING ATHEROSCLEROSIS, PERIPHERAL VASCULAR DISEASE, OBESITY PFIZER (US) 2000-10-31 US disclosed