Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | MTNR1A | P48039 | 17/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 17/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588525 | 1.00 | PIM1 (0.55) | PIM1PIM3PIM2MTNR1AMTNR1B | |
| SCHEMBL6579816 | 0.85 | MTNR1A (0.73) | MTNR1AMTNR1BACACBDRD2HTR2A | |
| SCHEMBL6579808 | 0.85 | MTNR1A (0.73) | MTNR1AMTNR1BACACBDRD2HTR2A | |
| SCHEMBL6582110 | 0.83 | MTNR1A (0.74) | MTNR1AMTNR1BACACB | |
| SCHEMBL6582109 | 0.83 | MTNR1A (0.74) | MTNR1AMTNR1BACACB | |
| SCHEMBL6583078 | 0.82 | MTNR1A (0.75) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL6582697 | 0.82 | MTNR1A (0.75) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL12283936 | 0.81 | PIM1 (0.67) | PIM1PIM3PIM2MTNR1AMTNR1B | |
| SCHEMBL6583016 | 0.81 | MTNR1A (0.74) | MTNR1AMTNR1BDRD2HTR2ADRD3 | |
| SCHEMBL6583011 | 0.81 | MTNR1A (0.74) | MTNR1AMTNR1BDRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1189900-B1 | HETEROCYCLIC AMINOPYRROLIDINE DERIVATIVES AS MELATONERGIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-01-14 | — | — | EP | disclosed |
| US-6211225-B1 | SLEEP DISORDERS AND CIRCADIAN RHYTHM DISORDERS | BRISTOL-MEYERS SQUIBB | 2001-04-03 | — | — | US | disclosed |