Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.77 |
| ▸ | RAB9A | P51151 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 6/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30369924 | 1.00 | HDAC1 (0.77) | HDAC1RAB9ANPC1SMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL29693057 | 0.98 | HDAC1 (0.74) | HDAC1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL30739586 | 0.89 | HDAC1 (0.75) | HDAC1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL30739990 | 0.88 | RAB9A (0.72) | HDAC1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL29903248 | 0.87 | HDAC1 (1.00) | HDAC1MEN1KMT2A | |
| SCHEMBL15553332 | 0.87 | HDAC1 (1.00) | HDAC1MEN1KMT2A | |
| SCHEMBL30370145 | 0.86 | HDAC1 (0.71) | HDAC1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL23273772 | 0.85 | HDAC1 (0.69) | HDAC1RAB9ANPC1MAPTPOLB | |
| SCHEMBL24769824 | 0.85 | EPHX1 (0.57) | HDAC1RAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL19392337 | 0.83 | NPC1 (0.71) | HDAC1RAB9ANPC1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017197088-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS | PHARMAKEA, INC. (US) | 2017-11-16 | — | — | WO | disclosed |
| EP-3160465-A1 | USE OF SMALL MOLECULES FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE TOXICITY | The Board of Trustees of the Leland Stanford Junior University (US) | 2017-05-03 | — | — | EP | disclosed |
| WO-2015200358-A1 | USE OF SMALL MOLECULES FOR THE TREATMENT OF CLOSTRIDIUM DIFFICILE TOXICITY | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2015-12-30 | — | — | WO | disclosed |
| EP-1379234-A1 | HALOGENATED AMINOBENZOPHENONES AND AMINOBENZOYLPYRIDINES AS INHIBITORS OF IL-1 AND TNF | Novartis AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002076447-A1 | HALLOGENATED AMINOBENZOPHENONES AND AMINOBENZOYLPYRIDINES AS INHIBITORS OF IL-1 AND TNF | NOVARTIS AG (CH) | 2002-10-03 | — | — | WO | disclosed |
| EP-0818439-B1 | Imide derivatives | NISSHIN FLOUR MILLING CO (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5847123-A | Imide derivatives for inhibiting the production of interleukin-1β and the production of tumor necrosis factor α | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| EP-0818439-A2 | Imide derivatives | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-01-14 | — | — | EP | disclosed |