Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA7 | P43166 | 1/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594756 | 0.93 | CA1 (0.62) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6596190 | 0.86 | ABCC9 (0.53) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6593867 | 0.83 | CA1 (0.57) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6590513 | 0.82 | MALT1 (0.49) | CA1CA2CA12CA7CA14 | |
| SCHEMBL4257830 | 0.82 | MAPT (0.51) | CA1CA2CA12CA7CA14 | |
| SCHEMBL4259500 | 0.80 | ABCC9 (0.56) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6590576 | 0.80 | MAPT (0.61) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6596251 | 0.80 | MAPT (0.49) | CA1CA2CA12CA7CA14 | |
| SCHEMBL6591042 | 0.80 | MAPT (0.49) | CA1CA2CA12CA7CA14 | |
| SCHEMBL4267588 | 0.79 | MAPT (0.48) | CA1CA2CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842927-B1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | AVENTIS PHARMA GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| CN-1101815-C | 3 -amidochromanylsulfonyl (thio) ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AG (DE) | 2003-02-19 | — | — | CN | disclosed |
| US-5849755-A | 3-amidochromanylsulfonyl(thio)ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-12-15 | — | — | US | disclosed |
| CN-1182741-A | 3 -amidochromanylsulfonyl (thio) ureas, processes for their preparation, their use, and pharmaceutical preparations comprising them | HOECHST AG (DE) | 1998-05-27 | — | — | CN | disclosed |
| EP-0842927-A1 | 3-Amido-chromanylsulfonyl(thio)ureas, process for their preparation, their use and medicaments containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-20 | — | — | EP | disclosed |