SCHEMBL6588871

SCHEMBL6588871

CCCC(=O)c1cc(C(=O)O)ccc1OC

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57
CA4 P22748 1/20 0.57
CA6 P23280 1/20 0.57
CA7 P43166 1/20 0.57
TPMT P51580 1/20 0.57
CA9 Q16790 1/20 0.57
CA14 Q9ULX7 1/20 0.57
TSHR P16473 2/20 0.56
HTT P42858 2/20 0.53
LMNA P02545 2/20 0.53
MAPK1 P28482 1/20 0.53
RAB9A P51151 1/20 0.53
ALDH1A1 P00352 1/20 0.50
CTNNB1 P35222 1/20 0.48
WNT3A P56704 1/20 0.48
TTR P02766 1/20 0.48
PKM P14618 1/20 0.48
PDE4D Q08499 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5325908 0.88 CTNNB1 (0.55) CA12CA1CA2CA4CA6
SCHEMBL3618826 0.88 CA12 (0.57) CA12CA1CA2CA4CA6
SCHEMBL17211733 0.88 CA12 (0.57) CA12CA1CA2CA4CA6
SCHEMBL7015913 0.87 CA12 (0.61) CA12CA1CA2CA4CA6
SCHEMBL7012914 0.86 TSHR (0.59) TSHRLMNARAB9AALDH1A1
SCHEMBL7009493 0.85 PTPN11 (0.54) TSHRALDH1A1
SCHEMBL7013940 0.84 KMT2A (0.45) CA12CA1CA2CA4CA6
SCHEMBL901309 0.81 CA12 (0.71) CA12CA1CA2CA4CA6
SCHEMBL29446743 0.81 CA12 (0.71) CA12CA1CA2CA4CA6
SCHEMBL13753192 0.81 KMT2A (0.58) TSHRHTTLMNARAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144409-B1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2004-11-17 EP disclosed
EP-1150977-B1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2004-08-25 EP disclosed
US-6699879-B1 OBESITY, DIABETES, SLEEP DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2004-03-02 US disclosed
US-6596730-B1 Phenyl urea and phenyl thiourea derivatives SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-22 US disclosed
EP-1102769-B1 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM PLC (GB) 2003-04-16 EP disclosed
EP-1150977-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2001-11-07 EP disclosed
EP-1144409-A2 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2001-10-17 EP disclosed
EP-1102769-A2 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM PLC (GB) 2001-05-30 EP disclosed
WO-2000047577-A1 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-08-17 WO disclosed
WO-2000047580-A2 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES SMITHKLINE BEECHAM PLC (GB) 2000-08-17 WO disclosed
WO-2000008020-A2 TRICYCLIC CARBOXAMIDES SMITHKLINE BEECHAM P.L.C. (GB) 2000-02-17 WO disclosed