Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 7/20 | 0.64 |
| ▸ | ACHE | P22303 | 7/20 | 0.64 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25191376 | 0.79 | BCHE (0.83) | BCHEACHEABCG2MAOB | |
| SCHEMBL25194946 | 0.79 | BCHE (0.83) | BCHEACHEABCG2MAOB | |
| SCHEMBL25279110 | 0.79 | BCHE (0.83) | BCHEACHEABCG2MAOB | |
| SCHEMBL4845554 | 0.79 | ABCG2 (0.73) | BCHEACHEABCG2TNFRSF1AMAPT | |
| SCHEMBL4851201 | 0.79 | ABCG2 (0.73) | BCHEACHEABCG2TNFRSF1AMAPT | |
| SCHEMBL4846087 | 0.79 | BCHE (0.68) | BCHEACHEABCG2LMNAMAPT | |
| SCHEMBL4847840 | 0.79 | BCHE (0.68) | BCHEACHEABCG2LMNAMAPT | |
| SCHEMBL4845561 | 0.77 | ABCG2 (0.73) | BCHEACHEABCG2TNFRSF1AKDM4E | |
| SCHEMBL4857406 | 0.77 | BCHE (0.58) | BCHEACHEABCG2CXCL12MAOB | |
| SCHEMBL4846784 | 0.77 | BCHE (0.58) | BCHEACHEABCG2CXCL12MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432699-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003022832-A1 | PYRIDYLFURANS AND PYRROLES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-03-20 | — | — | WO | disclosed |