Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29773210 | 0.93 | DRD3 (0.55) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| SCHEMBL3991767 | 0.93 | DRD3 (0.55) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| SCHEMBL3991771 | 0.93 | DRD3 (0.55) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL6586295 | 0.91 | KMT2A (0.54) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| Phosphoric Acid SCHEMBL3996517 | 0.90 | DRD3 (0.53) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| Phosphoric Acid SCHEMBL3996528 | 0.90 | DRD3 (0.53) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| SCHEMBL6587232 | 0.89 | SIGMAR1 (0.51) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| SCHEMBL6587045 | 0.87 | DRD4 (0.57) | KMT2AMEN1DRD3DRD2DRD4 | |
| SCHEMBL6587983 | 0.86 | KDM4E (0.53) | KMT2AMEN1DRD3SIGMAR1DRD2 | |
| Hydrochloric Acid SCHEMBL6007678 | 0.86 | KDM4E (0.53) | KMT2AMEN1DRD3SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1186601-B1 | NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMA CO LTD (JP) | 2004-03-24 | — | — | EP | claimed |
| US-6573279-B1 | Drug, particularly to a novel isoquinoline derivative or its salt having an If current inhibitory effect without serious side effects such as convulsion and also to a drug, particularly a cardiac rate lowering agent, containing the | ASTELLAS PHARMA INC. (JP) | 2003-06-03 | — | — | US | claimed |
| EP-1186601-A1 | NOVEL ISOQUINOLINE DERIVATIVES OR SALTS THEREOF | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2002-03-13 | — | — | EP | claimed |