Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323044 | 0.76 | NOTUM (0.55) | KDM4EALDH1A1MAPK1NOTUMLRRK2 | |
| SCHEMBL8425453 | 0.73 | CAPN1 (0.47) | KDM4EALDH1A1MAPK1NOTUMLRRK2 | |
| SCHEMBL5830804 | 0.72 | KDM5A (0.38) | KDM4EALDH1A1MAPK1LMNA | |
| SCHEMBL2161445 | 0.70 | LMNA (0.56) | KDM4EALDH1A1MAPK1NOTUMLRRK2 | |
| SCHEMBL16595887 | 0.70 | NOTUM (0.51) | KDM4EALDH1A1MAPK1NOTUMLMNA | |
| SCHEMBL31173853 | 0.70 | LMNA (0.56) | KDM4EALDH1A1MAPK1NOTUMLRRK2 | |
| SCHEMBL4341894 | 0.70 | NOTUM (0.78) | KDM4EALDH1A1MAPK1NOTUMLMNA | |
| SCHEMBL7736097 | 0.69 | NOTUM (0.46) | KDM4EALDH1A1MAPK1NOTUMMGLL | |
| SCHEMBL4707233 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMLRRK2 | |
| SCHEMBL5717609 | 0.69 | KDM4E (0.50) | KDM4EALDH1A1MAPK1NOTUMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465864-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003045912-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | WARNER-LAMBERT COMPANY LLC (US) | 2003-06-05 | — | — | WO | disclosed |