Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | TSHR | P16473 | 2/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.75 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.75 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.75 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.75 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.75 |
| ▸ | VKORC1 | Q9BQB6 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dicumarol SCHEMBL33891 | 0.86 | NQO1 (1.00) | NQO1ALDH1A1LMNATP53TSHR | |
| Dicumarol SCHEMBL7454901 | 0.86 | NQO1 (1.00) | NQO1ALDH1A1LMNATP53TSHR | |
| Dicumarol SCHEMBL29703314 | 0.86 | NQO1 (1.00) | NQO1ALDH1A1LMNATP53TSHR | |
| Dicumarol SCHEMBL17927706 | 0.84 | NQO1 (0.96) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL1707603 | 0.84 | NQO1 (0.56) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL2052391 | 0.83 | NQO1 (0.65) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL14169915 | 0.83 | NQO1 (0.75) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL9526995 | 0.83 | NQO1 (0.75) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL14078666 | 0.82 | NQO1 (0.69) | NQO1ALDH1A1LMNATP53TSHR | |
| SCHEMBL15851235 | 0.82 | ALDH1A1 (0.63) | NQO1ALDH1A1LMNATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071142-A1 | IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE TRANSCRIPTION FACTOR FUNCTION AND TO TREAT TRANSCRIPTION FACTOR ASSOCIATED DISEASES | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2011-03-24 | — | — | US | disclosed |
| US-6689799-B1 | NON-NUCLEOSIDE-DERIVATIVE VIRICIDES | REPHARTOX (NL) | 2004-02-10 | — | — | US | disclosed |
| EP-1214315-B9 | 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF | REPHARTOX (NL) | 2004-01-02 | — | — | EP | disclosed |
| EP-1214315-B1 | 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF | REPHARTOX (NL) | 2003-05-02 | — | — | EP | disclosed |
| EP-1214315-A1 | 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF | Rephartox (NL) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001014370-A1 | 1,4-DIHYDROPYRIDINE-5-CARBOXYLIC ACID ESTER DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF | REPHARTOX (NL) | 2001-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071142-A1 | IDENTIFICATION AND USE OF SMALL MOLECULES TO MODULATE TRANSCRIPTION FACTOR FUNCTION AND TO TREAT TRANSCRIPTION FACTOR ASSOCIATED DISEASES | CREBBP, TEAD1, SREBF1 | NQO1 1534/4885ALDH1A1 3041/4885LMNA 2173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.