SCHEMBL6589422

SCHEMBL6589422

O=C(Nc1ccc(Cl)cc1)c1cc(Cl)ccc1NC(=O)c1sc(CBr)cc1Cl

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.70
F2 P00734 8/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6592797 0.90 F10 (0.71) F10F2
SCHEMBL7449684 0.86 F10 (0.52) F10F2
SCHEMBL6593537 0.86 F10 (0.69) F10F2
SCHEMBL6590326 0.86 F10 (0.69) F10F2
SCHEMBL6589146 0.85 F10 (0.68) F10F2
SCHEMBL6593542 0.84 F10 (0.67) F10F2
SCHEMBL6592947 0.83 F10 (0.62) F10F2
SCHEMBL6591746 0.82 F10 (1.00) F10F2
SCHEMBL6590565 0.81 F10 (0.63) F10F2
SCHEMBL6590802 0.81 F10 (0.69) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed