Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.42 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591928 | 0.88 | BACE1 (0.61) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6587931 | 0.83 | BACE1 (0.49) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6590512 | 0.83 | BACE1 (0.49) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6584810 | 0.81 | BACE1 (0.54) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6599494 | 0.80 | BACE1 (0.49) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6589904 | 0.77 | BACE1 (0.53) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6591279 | 0.77 | BACE1 (0.53) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6590442 | 0.76 | BACE1 (0.49) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL6588437 | 0.74 | BACE1 (0.50) | BACE1BACE2KMT2ALMNAGLA | |
| SCHEMBL8183941 | 0.74 | BACE1 (0.58) | BACE1BACE2KMT2ALMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066279-A4 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1066279-A1 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6054590-A | NEUROPEPTIDE Y (NPY) ANTAGONISTS FOR TREATMENT OF EATING DISORDERS AND PROMOTING WEIGHT LOSS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999048888-A1 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |