Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 5/20 | 0.54 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591928 | 0.89 | BACE1 (0.61) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6588437 | 0.82 | BACE1 (0.50) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6591279 | 0.81 | BACE1 (0.53) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6589473 | 0.81 | BACE1 (0.53) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6590512 | 0.81 | BACE1 (0.49) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL8235054 | 0.78 | BACE1 (0.83) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6589904 | 0.78 | BACE1 (0.53) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6599494 | 0.78 | BACE1 (0.49) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6587050 | 0.77 | LMNA (0.51) | BACE1BACE2CYP2C9BLMPMP22 | |
| SCHEMBL6587379 | 0.76 | BACE1 (0.47) | BACE1BACE2CYP2C9BLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066278-A4 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1066278-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| WO-1999048887-A1 | IMIDAZOLONE ANORECTIC AGENTS: III. HETEROARYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |