Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3695255 | 0.94 | KMT2A (0.54) | KMT2AMEN1RECQLRAB9AMAPT | |
| SCHEMBL31436853 | 0.80 | MAPT (0.60) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL17831407 | 0.77 | KMT2A (0.51) | KMT2AMEN1RECQLRAB9AMAPT | |
| SCHEMBL29489449 | 0.76 | RAB9A (0.66) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL59952 | 0.76 | RAB9A (0.66) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL2082944 | 0.75 | KMT2A (0.58) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL2477935 | 0.74 | NPC1 (0.57) | KMT2AMEN1RAB9AMAPTNPC1 | |
| SCHEMBL6297661 | 0.74 | RAB9A (0.72) | KMT2AMEN1RAB9AMAPTPOLB | |
| SCHEMBL30825949 | 0.73 | MAPT (0.50) | KMT2AMEN1RAB9AMAPTPOLB | |
| SCHEMBL3069292 | 0.73 | MAPT (0.50) | KMT2AMEN1RAB9AMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465864-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003045912-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | WARNER-LAMBERT COMPANY LLC (US) | 2003-06-05 | — | — | WO | disclosed |