Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.70 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 1/20 | 0.52 |
| ▸ | MMP13 | P45452 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468696 | 0.95 | MEN1 (0.77) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL30737179 | 0.88 | KMT2A (0.88) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL2821240 | 0.88 | KMT2A (0.88) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL4531038 | 0.83 | MEN1 (0.64) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL34474241 | 0.83 | KMT2A (0.94) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL12481279 | 0.83 | KMT2A (0.94) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL15334448 | 0.83 | KMT2A (1.00) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL4733033 | 0.81 | MEN1 (0.68) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL22042382 | 0.81 | MEN1 (0.64) | MEN1KMT2ACA1CA2MMP1 | |
| SCHEMBL14163384 | 0.81 | KMT2A (0.97) | MEN1KMT2ACA1CA2MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169338-B1 | LOW-MOLECULAR INHIBITORS OF COMPLEMENT PROTEASES | ABBOTT GMBH & CO KG (DE) | 2004-11-03 | — | — | EP | disclosed |