Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 5/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 2/20 | 0.40 |
| ▸ | PRKCA | P17252 | 2/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590140 | 0.79 | CDK4 (0.52) | MAPK1TDP1CDK4CDK6ALDH1A1 | |
| SCHEMBL7004515 | 0.78 | SIRT2 (0.43) | TDP1CDK4ALDH1A1GAAPDGFRB | |
| SCHEMBL12045736 | 0.77 | HSP90AA1 (0.72) | TDP1ALDH1A1KDM4EHSP90AA1POLB | |
| SCHEMBL13808327 | 0.76 | HSP90AA1 (0.60) | HSP90AA1 | |
| SCHEMBL13983107 | 0.75 | HSP90AA1 (0.62) | TDP1HSP90AA1HCAR1 | |
| SCHEMBL13983148 | 0.75 | HSP90AA1 (0.65) | TDP1HSP90AA1HCAR1 | |
| SCHEMBL13983100 | 0.74 | HSP90AA1 (0.46) | TDP1ALDH1A1GAAHSP90AA1POLB | |
| SCHEMBL12045810 | 0.73 | HSP90AA1 (0.60) | HSP90AA1 | |
| SCHEMBL8185947 | 0.73 | TDP1 (0.44) | MAPK1TDP1ALDH1A1KDM4EPOLB | |
| SCHEMBL7822667 | 0.71 | CDK4 (0.41) | CDK4CDK6GAAPDGFRBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| US-6492406-B1 | PROTEIN KINASE C INHIBITORS; ANTIINFLAMMATORY AND IMMUNO-SUPPRESSIVE AGENTS | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1183252-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000071537-A1 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-30 | — | — | WO | disclosed |