Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 2/20 | 0.37 |
| ▸ | PRKCA | P17252 | 2/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | PRKACA | P17612 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976408 | 0.82 | MEN1 (0.40) | CDK4METEGFRBRAFCDK6 | |
| SCHEMBL7004515 | 0.77 | SIRT2 (0.43) | CDK4SIRT2SIRT1MEN1KMT2A | |
| SCHEMBL7820421 | 0.72 | PDE9A (0.40) | CDK4METEGFRBRAFCDK6 | |
| SCHEMBL6589577 | 0.71 | MAPK1 (0.45) | CDK4CDK6SIRT2SIRT1MEN1 | |
| Acetic Acid SCHEMBL7840658 | 0.69 | NPEPPS (0.33) | CAMK2DITGA4ITGB7 | |
| SCHEMBL7819614 | 0.68 | MPO (0.36) | CDK4METEGFRBRAFCDK6 | |
| SCHEMBL6976268 | 0.68 | NPEPPS (0.63) | GAAHCAR1 | |
| SCHEMBL7821934 | 0.66 | PDE9A (0.33) | CDK4METEGFRBRAFCDK6 | |
| SCHEMBL7010190 | 0.65 | NT5E (0.45) | CDK4SIRT2SIRT1MEN1KMT2A | |
| SCHEMBL29326335 | 0.65 | NPEPPS (0.43) | PIM1GAAMCL1ITGA4ITGB7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1095039-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | AstraZeneca AB (SE) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000002877-A2 | NEW PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-01-20 | — | — | WO | disclosed |