Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 16/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587558 | 0.88 | BCHE (0.53) | ROCK1CLK4MAPT | |
| SCHEMBL6590857 | 0.88 | RAF1 (0.50) | CNR1RAF1METPDGFRBCDK8 | |
| SCHEMBL6588831 | 0.87 | MEN1 (0.52) | CNR1RAF1METPDGFRBCDK8 | |
| SCHEMBL6586829 | 0.87 | MAPT (0.47) | CNR1RAF1METPDGFRBCDK8 | |
| SCHEMBL6587567 | 0.87 | CNR1 (0.56) | CNR1RAF1METPDGFRBCDK8 | |
| SCHEMBL6198977 | 0.83 | HTR2A (0.59) | ROCK1NTRK2AURKBCLK4HTR2A | |
| SCHEMBL6590586 | 0.81 | PDE5A (0.43) | METPDGFRBCDK8ROCK1NTRK3 | |
| SCHEMBL6585335 | 0.80 | BDKRB1 (0.53) | MAPT | |
| SCHEMBL6585533 | 0.80 | MEN1 (0.53) | MAPT | |
| SCHEMBL6587091 | 0.79 | KIT (0.50) | ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |