Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590232 | 0.80 | CNR1 (0.59) | MAPT | |
| SCHEMBL2950544 | 0.80 | L3MBTL1 (0.56) | MEN1KMT2AKDM4EPARP1LMNA | |
| SCHEMBL6590857 | 0.79 | RAF1 (0.50) | SMN1; SMN2KDRPDGFRA | |
| SCHEMBL6586829 | 0.78 | MAPT (0.47) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL6585335 | 0.78 | BDKRB1 (0.53) | NPC1MAPTRAB9A | |
| SCHEMBL6588831 | 0.78 | MEN1 (0.52) | MEN1KMT2ALMNANPC1MAPT | |
| SCHEMBL6587567 | 0.78 | CNR1 (0.56) | MEN1KMT2AKDM4ELMNAPKM | |
| SCHEMBL6585535 | 0.78 | KDM4E (0.53) | MEN1KMT2AKDM4EPARP1LMNA | |
| SCHEMBL6587091 | 0.77 | KIT (0.50) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6587933 | 0.76 | RAB9A (0.48) | MEN1KMT2AALDH1A1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1244632-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | Arena Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001029008-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | ARENA PHARMACEUTICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |