Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.77 |
| ▸ | BRD2 | P25440 | 1/20 | 0.77 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | INMT | O95050 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpyrrolidone SCHEMBL7609358 | 0.93 | BRD4 (0.81) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL28843561 | 0.92 | BRD4 (0.65) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL6289120 | 0.90 | BRD4 (0.68) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL487 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL8055062 | 0.88 | BRD4 (1.00) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL5423326 | 0.88 | — | — | |
| Methylpyrrolidone SCHEMBL1255511 | 0.88 | BRD4 (1.00) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL3004368 | 0.86 | BRD4 (0.77) | BRD4BRD2PIK3CDINMTLMNA | |
| Methylpyrrolidone SCHEMBL9634127 | 0.86 | — | — | |
| Methylpyrrolidone SCHEMBL28183883 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379519-A1 | PYRROLIDINE SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-1379237-A2 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078641-A2 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |
| WO-2002079188-A1 | PYRROLIDINE SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | disclosed |