Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7381678 | 0.89 | KDM4E (0.53) | L3MBTL1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL6588825 | 0.87 | AURKA (0.54) | L3MBTL1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL16832379 | 0.84 | ADORA2A (0.47) | ADORA2AKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL16832388 | 0.81 | GRM2 (0.56) | ADORA2AKDM4EPSMD14AURKA | |
| SCHEMBL7487026 | 0.77 | KDM4E (0.68) | L3MBTL1KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL22492423 | 0.75 | PSMD14 (0.68) | L3MBTL1ADORA2AKDM4ENPSR1NPC1 | |
| SCHEMBL2222961 | 0.73 | ADORA2A (0.47) | ADORA2AKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL3990345 | 0.72 | ADORA2A (0.38) | ADORA2AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL3281586 | 0.72 | NQO2 (0.47) | ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL2222480 | 0.72 | ADORA2A (0.47) | ADORA2AKDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| US-6699879-B1 | OBESITY, DIABETES, SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1150977-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000047577-A1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-17 | — | — | WO | disclosed |