Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 7/20 | 0.33 |
| ▸ | MAP2K7 | O14733 | 5/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | HAO2 | Q9NYQ3 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586551 | 0.91 | AURKA (0.36) | MAP2K4MAP2K7AURKA | |
| SCHEMBL6589050 | 0.89 | HSP90AA1 (0.35) | MAP2K4PTGDR2GAAAURKAAURKB | |
| SCHEMBL6588992 | 0.85 | SMN1; SMN2 (0.36) | GAA | |
| SCHEMBL6591159 | 0.83 | TTK (0.35) | MAP2K7AURKA | |
| SCHEMBL6586587 | 0.83 | BRAF (0.35) | GAA | |
| SCHEMBL6585177 | 0.83 | MAP2K4 (0.35) | MAP2K4MAP2K7KITHAO2AURKA | |
| SCHEMBL2958214 | 0.80 | L3MBTL1 (0.47) | CSNK1D | |
| SCHEMBL6586575 | 0.79 | MAPT (0.35) | MAP2K4GAAAURKAAURKB | |
| SCHEMBL6586014 | 0.76 | PDE5A (0.33) | MAP2K4MAP2K7AURKA | |
| SCHEMBL6591221 | 0.75 | SMN1; SMN2 (0.54) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071701-A4 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARM INC (US) | 2004-04-21 | — | — | EP | disclosed |
| EP-1244632-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | Arena Pharmaceuticals, Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001029008-A1 | PYRAZOLE DERIVATIVES WHICH MODULATE HUMAN SEROTONIN RECEPTORS | ARENA PHARMACEUTICALS, INC. (US) | 2001-04-26 | — | — | WO | disclosed |
| EP-1071701-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999052927-A1 | NON-ENDOGENOUS, CONSTITUTIVELY ACTIVATED HUMAN SEROTONIN RECEPTORS AND SMALL MOLECULE MODULATORS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 1999-10-21 | — | — | WO | disclosed |