Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 3/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599494 | 0.84 | BACE1 (0.49) | BACE1MAOBBACE2LMNAGLA | |
| SCHEMBL6591928 | 0.80 | BACE1 (0.61) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL8183941 | 0.80 | BACE1 (0.58) | BACE1BACE2CTSDLMNAGLA | |
| SCHEMBL6593173 | 0.78 | KMT2A (0.49) | BACE1MAOBBACE2LMNAGLA | |
| SCHEMBL6587931 | 0.78 | BACE1 (0.49) | BACE1MAOBBACE2CTSDLMNA | |
| SCHEMBL6600448 | 0.78 | BACE1 (0.49) | BACE1BACE2CTSDLMNAGLA | |
| SCHEMBL6591931 | 0.78 | BACE1 (0.49) | BACE1BACE2CTSDLMNAGLA | |
| SCHEMBL6593802 | 0.78 | BACE1 (0.49) | BACE1BACE2LMNAGLATHRB | |
| SCHEMBL6595107 | 0.76 | KMT2A (0.46) | BACE1MAOBBACE2LMNAGLA | |
| SCHEMBL6590716 | 0.75 | LMNA (0.45) | BACE1MAOBBACE2LMNAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1066279-A4 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1066279-A1 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | Bristol-Myers Squibb Company (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6054590-A | NEUROPEPTIDE Y (NPY) ANTAGONISTS FOR TREATMENT OF EATING DISORDERS AND PROMOTING WEIGHT LOSS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-25 | — | — | US | disclosed |
| WO-1999048888-A1 | IMIDAZOLONE ANORECTIC AGENTS: II. PHENYL DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-09-30 | — | — | WO | disclosed |