Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.40 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10574079 | 0.76 | HTR2A (0.62) | TAAR1 | |
| SCHEMBL9232873 | 0.74 | HRH3 (0.59) | SLC18A2ADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL7951503 | 0.73 | ADRA1D (0.48) | SLC18A2ADRA1DADRA1AADRA1BSIGMAR1 | |
| SCHEMBL10574076 | 0.70 | HRH3 (0.62) | — | |
| SCHEMBL3047898 | 0.69 | CYP1A2 (0.62) | DAOTDP1 | |
| SCHEMBL2378007 | 0.68 | TDP1 (0.55) | ADRA1DADRA1AADRA1BSIGMAR1TDP1 | |
| SCHEMBL9030269 | 0.67 | HSD17B10 (0.45) | ADRA1DADRA1AADRA1BSIGMAR1 | |
| Hydrochloric Acid SCHEMBL17444674 | 0.67 | TDP1 (0.54) | ADRA1DADRA1AADRA1BSIGMAR1TDP1 | |
| SCHEMBL16358059 | 0.67 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BSIGMAR1DAO | |
| SCHEMBL134400 | 0.66 | CYP1A2 (0.54) | TDP1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1226137-B1 | PHENYL- AND PYRIDYL-TETRAHYDRO-PYRIDINES HAVING TNF INHIBITING ACTIVITY | SANOFI SYNTHELABO (FR) | 2004-07-21 | — | — | EP | disclosed |