Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | IGF1R | P08069 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586520 | 0.88 | IGF1R (0.79) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6585168 | 0.87 | MAPT (0.61) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6592577 | 0.86 | IGF1R (0.65) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL4855474 | 0.85 | HTT (0.75) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL7690789 | 0.85 | IGF1R (0.67) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6591375 | 0.83 | S1PR1 (0.63) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6592545 | 0.83 | IGF1R (0.79) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6587428 | 0.82 | IGF1R (0.70) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6586314 | 0.82 | BRAF (0.70) | NPC1RAB9AMEN1KMT2AIGF1R | |
| SCHEMBL6588598 | 0.82 | IGF1R (0.77) | NPC1RAB9AMEN1KMT2AIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150977-B1 | PHENYL UREA AND PHENYL THIOUREA DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | claimed |