Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 9/20 | 0.41 |
| ▸ | CTSL | P07711 | 7/20 | 0.41 |
| ▸ | CTSS | P25774 | 7/20 | 0.41 |
| ▸ | CTSB | P07858 | 5/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428085 | 0.90 | CTSK (0.41) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4924362 | 0.84 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7633224 | 0.84 | CTSK (0.56) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL5092610 | 0.83 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4839973 | 0.81 | CTSK (0.49) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL4839956 | 0.81 | CTSK (0.40) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL7428075 | 0.80 | CTSK (0.43) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6765207 | 0.79 | CYP3A4 (0.45) | CTSKGAAALDH1A1MAPT | |
| SCHEMBL7481625 | 0.78 | CTSK (0.39) | CTSKCTSLCTSSCTSBCTSV | |
| SCHEMBL6761962 | 0.77 | POLB (0.46) | CTSKCTSLCTSSCTSBCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |