SCHEMBL6591074

SCHEMBL6591074

COc1cc(N)c(Br)cc1C(=O)NC1CCN(C(C(=O)N(C)C)C2CCNCC2)CC1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR4 Q13639 13/20 0.52
ACHE P22303 3/20 0.42
CYP1A2 P05177 2/20 0.42
ADRA2A P08913 2/20 0.42
CYP2D6 P10635 2/20 0.42
DRD3 P35462 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2C9 P11712 1/20 0.42
DRD2 P14416 1/20 0.42
ADRA2B P18089 1/20 0.42
ADRA2C P18825 1/20 0.42
DRD4 P21917 1/20 0.42
SLC6A2 P23975 1/20 0.42
HTR2A P28223 1/20 0.42
HTR2C P28335 1/20 0.42
ADRA1A P35348 1/20 0.42
OPRK1 P41145 1/20 0.42
HTR2B P41595 1/20 0.42
CHRNA4 P43681 1/20 0.42
HTR3A P46098 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7903253 0.90 HTR4 (0.55) HTR4ACHECYP1A2ADRA2ACYP2D6
SCHEMBL6588490 0.90 HTR4 (0.57) HTR4ACHECYP1A2ADRA2ACYP2D6
SCHEMBL6590685 0.90 HTR4 (0.68) HTR4ACHECYP1A2ADRA2ACYP2D6
SCHEMBL6586470 0.87 HTR4 (0.52) HTR4ACHECYP1A2ADRA2ACYP2D6
SCHEMBL6587854 0.86 HTR4 (0.51) HTR4ACHECYP1A2ADRA2ACYP2D6
SCHEMBL6584501 0.86 HTR4 (0.50) HTR4ACHECYP1A2ADRA2ACYP2D6
Fumaric Acid SCHEMBL6588346 0.85 HTR4 (0.61) HTR4ACHECYP1A2ADRA2ACYP2D6
Fumaric Acid SCHEMBL6588045 0.85 HTR4 (0.48) HTR4ACHECYP1A2ADRA2ACYP2D6
Fumaric Acid SCHEMBL6590852 0.84 HTR4 (0.49) HTR4ACHECYP1A2ADRA2ACYP2D6
Fumaric Acid SCHEMBL6586298 0.83 HTR4 (0.47) HTR4ACHECYP1A2ADRA2ACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP claimed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US claimed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP claimed
EP-1076055-B1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS DAINIPPON PHARMACEUTICAL CO (JP) 2004-11-24 EP disclosed
US-6294555-B1 SEROTONIN HT3 RECEPTOR ANTAGONIST FOR GASTROINTESTINAL DISORDERS DAINIPPON PHARMACEUTICAL CO., LTD. (JP) 2001-09-25 US disclosed
EP-1076055-A1 1- (1-SUBSTITUTED-4-PIPERIDINYL)METHYL]-4-PIPERIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES OF THESE COMPOUNDS Dainippon Pharmaceutical Co., Ltd. (JP) 2001-02-14 EP disclosed