Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 4/20 | 0.61 |
| ▸ | CDK2 | P24941 | 15/20 | 0.58 |
| ▸ | CDK4 | P11802 | 5/20 | 0.58 |
| ▸ | CDK1 | P06493 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599115 | 0.92 | CDK2 (0.58) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6595912 | 0.92 | CDK2 (0.59) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6598403 | 0.88 | ABL1 (0.51) | IKBKBCDK2CDK4CDK1ABL1 | |
| SCHEMBL6295111 | 0.88 | CDK2 (0.68) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6596998 | 0.87 | CDK2 (0.54) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6595834 | 0.84 | CDK2 (0.81) | IKBKBCDK2CDK4CDK1CA12 | |
| SCHEMBL27512174 | 0.83 | CDK2 (0.49) | CDK2CDK4CDK1 | |
| SCHEMBL6103355 | 0.83 | CDK2 (0.69) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6104447 | 0.80 | CDK2 (0.81) | IKBKBCDK2CDK4CDK1 | |
| SCHEMBL6595576 | 0.80 | CDK2 (0.77) | IKBKBCDK2CDK4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1269813-C | Imidazolo-5-yl-2-anilino-pyrimidines as agents for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | CN | disclosed |
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |