Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.37 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306573 | 0.92 | ESR1 (0.46) | ESR1ESR2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL12893250 | 0.88 | ESR1 (0.77) | ESR1ESR2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL13264420 | 0.88 | ESR1 (0.48) | ESR1ESR2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL19238848 | 0.87 | ESR1 (0.52) | ESR1ESR2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL27874941 | 0.76 | — | — | |
| SCHEMBL20033743 | 0.76 | CYP19A1 (0.41) | ALDH1A1L3MBTL1HSD11B1LMNACYP19A1 | |
| SCHEMBL19238852 | 0.75 | CYP2A6 (0.47) | ESR1ESR2ALDH1A1L3MBTL1HSD11B1 | |
| SCHEMBL24157288 | 0.74 | ESR1 (0.58) | ESR1ESR2ALDH1A1L3MBTL1SIGMAR1 | |
| SCHEMBL30877914 | 0.74 | ESR1 (0.58) | ESR1ESR2ALDH1A1L3MBTL1SIGMAR1 | |
| SCHEMBL30877902 | 0.74 | ESR1 (0.58) | ESR1ESR2ALDH1A1L3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215762-A1 | Siloxane polymer containing tethered levofloxacin | NDSU RESEARCH FOUNDATION | 2009-08-27 | — | — | US | claimed |
| US-8283432-B2 | Siloxane polymer containing tethered fluoroquinolone | NDSU RESEARCH FOUNDATION (US) | 2012-10-09 | — | — | US | disclosed |
| US-8278400-B2 | Antifouling materials containing cationic polysiloxanes | NDSU RESEARCH FOUNDATION (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120046313-A1 | SILOXANE POLYMER CONTAINING TETHERED FLUOROQUINOLONE | NDSU RESEARCH FOUNDATION | 2012-02-23 | — | — | US | disclosed |
| US-20100204399-A1 | ANTIFOULING MATERIALS CONTAINING CATIONIC POLYSILOXANES | NDSU RESEARCH FOUNDATION | 2010-08-12 | — | — | US | disclosed |
| US-7771833-B2 | Anti-fouling materials containing cationic polysiloxanes | NDSU RESEARCH FOUNDATION (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090215762-A1 | Siloxane polymer containing tethered levofloxacin | NDSU RESEARCH FOUNDATION | 2009-08-27 | — | — | US | disclosed |
| EP-1879972-A4 | ANTI-FOULING MATERIALS CONTAINING POLYAMINE CROSS-LINKED POLYSILOXANES | NDSU RES FOUNDATION (US) | 2008-10-15 | — | — | EP | disclosed |
| EP-1879972-A1 | ANTI-FOULING MATERIALS CONTAINING POLYAMINE CROSS-LINKED POLYSILOXANES | NDSU Research Foundation (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20070042199-A1 | Anti-fouling materials containing cationic polysiloxanes | NDSU RESEARCH FOUNDATION | 2007-02-22 | — | — | US | disclosed |
| WO-2006121937-A1 | ANTI-FOULING MATERIALS CONTAINING POLYAMINE CROSS-LINKED POLYSILOXANES | NDSU RESEARCH FOUNDATION (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046313-A1 | SILOXANE POLYMER CONTAINING TETHERED FLUOROQUINOLONE | QARS1, SEPTIN7, SMCHD1 | ESR1 375/4885ESR2 2518/4885ALDH1A1 3261/4885 |
| US-20090215762-A1 | Siloxane polymer containing tethered levofloxacin | PUF60, QARS1, SEPTIN7 | ESR1 1072/4885ESR2 3871/4885ALDH1A1 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.