SCHEMBL4306573

SCHEMBL4306573

c1cc(C2(c3ccncc3)CCC2)ccn1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.46
ESR2 Q92731 3/20 0.46
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
LMNA P02545 3/20 0.36
MAPT P10636 2/20 0.36
CHKA P35790 2/20 0.36
SIGMAR1 Q99720 1/20 0.36
CHRM5 P08912 1/20 0.35
OPRM1 P35372 1/20 0.34
CYP19A1 P11511 3/20 0.34
HSD11B1 P28845 2/20 0.34
NR1I2 O75469 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
CYP2D6 P10635 1/20 0.33
CHRM1 P11229 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL659326 0.92 ESR1 (0.54) ESR1ESR2ALDH1A1L3MBTL1LMNA
SCHEMBL13264420 0.81 ESR1 (0.48) ESR1ESR2ALDH1A1L3MBTL1CYP19A1
SCHEMBL12893250 0.81 ESR1 (0.77) ESR1ESR2ALDH1A1L3MBTL1LMNA
SCHEMBL19238848 0.80 ESR1 (0.52) ESR1ESR2ALDH1A1L3MBTL1LMNA
SCHEMBL28206644 0.75 CYP17A1 (0.37) ALDH1A1L3MBTL1LMNAOPRM1HSD11B1
SCHEMBL27881724 0.75 LMNA (0.33) ALDH1A1LMNAMAPTCHKASIGMAR1
SCHEMBL17469412 0.75 EPHX2 (0.41) L3MBTL1LMNAMAPTCHKASIGMAR1
SCHEMBL10002488 0.75 AKT1 (0.43)
Hydrochloric Acid SCHEMBL26916680 0.73 AKT1 (0.42)
SCHEMBL4312120 0.73 CHKA (0.32) LMNAMAPTCHKASIGMAR1CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7481866-B2 Gas storage materials and devices UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2009-01-27 US claimed
US-20090000474-A1 GAS STORAGE MATERIALS AND DEVICES NATIONAL SCIENCE FOUNDATION 2009-01-01 US claimed
JP-2006503104-A 2006-01-26 JP claimed
EP-1513612-A2 GAS STORAGE MATERIALS AND DEVICES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2005-03-16 EP claimed
WO-2004042270-A2 GAS STORAGE MATERIALS AND DEVICES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2004-05-21 WO claimed
US-7481866-B2 Gas storage materials and devices UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2009-01-27 US disclosed
US-20090000474-A1 GAS STORAGE MATERIALS AND DEVICES NATIONAL SCIENCE FOUNDATION 2009-01-01 US disclosed