Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CTSE | P14091 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65939 | 1.00 | REN (0.40) | RENCYP3A4SLC6A4CTSDCTSE | |
| SCHEMBL78437 | 0.90 | REN (0.42) | RENCYP3A4SLC6A4CTSDCTSE | |
| SCHEMBL65657 | 0.83 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL65658 | 0.83 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL64231 | 0.83 | REN (0.42) | RENCYP3A4CTSDCTSE | |
| SCHEMBL64232 | 0.83 | REN (0.42) | RENCYP3A4CTSDCTSE | |
| SCHEMBL65630 | 0.82 | REN (0.45) | RENCYP3A4 | |
| SCHEMBL65631 | 0.82 | REN (0.45) | RENCYP3A4 | |
| SCHEMBL65912 | 0.79 | REN (0.51) | RENCYP3A4 | |
| SCHEMBL65911 | 0.79 | REN (0.51) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |