Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | PRKCB | P05771 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | PRKACG | P22612 | 1/20 | 0.40 |
| ▸ | PRKACB | P22694 | 1/20 | 0.40 |
| ▸ | PRKCH | P24723 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506889 | 0.77 | AOC3 (0.46) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL3068361 | 0.75 | GRIK1 (0.49) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL4506884 | 0.73 | GRIK1 (0.45) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL3082016 | 0.73 | GRIK1 (0.45) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL8118597 | 0.73 | KDM4E (0.45) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL6589976 | 0.72 | MEN1 (0.40) | ALDH1A1GAAMAPK1MEN1KMT2A | |
| SCHEMBL927313 | 0.70 | AOC3 (0.46) | KDM4EHSD17B10LOXL2AOC3ALDH1A1 | |
| SCHEMBL5493171 | 0.70 | KDM4E (0.51) | KDM4EHSD17B10AOC3ALDH1A1GAA | |
| SCHEMBL4397993 | 0.70 | KMT2A (0.68) | HSD17B10ALDH1A1GAAMAPK1MEN1 | |
| SCHEMBL8671297 | 0.70 | GRIK1 (0.51) | KDM4EHSD17B10ALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944621-B1 | 2-IMIDAZOLINYLAMINOINDOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2004-09-01 | — | — | EP | disclosed |
| CN-1092652-C | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 2002-10-16 | — | — | CN | disclosed |
| CN-1238771-A | 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists | PROCTER & GAMBLE (US) | 1999-12-15 | — | — | CN | disclosed |