Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | DDO | Q99489 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5493171 | 0.82 | KDM4E (0.51) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL4506889 | 0.82 | AOC3 (0.46) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL4506884 | 0.79 | GRIK1 (0.45) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL5515054 | 0.79 | GRIK1 (0.51) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL9269321 | 0.76 | GRIK1 (0.56) | GRIK1KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL3068361 | 0.76 | GRIK1 (0.49) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL3073852 | 0.75 | GRIK1 (0.45) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL31487774 | 0.75 | MTNR1A (0.53) | GRIK1KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL3082016 | 0.75 | GRIK1 (0.45) | AOC3GRIK1KDM4EALDH1A1GAA | |
| SCHEMBL4413986 | 0.75 | MTNR1A (0.53) | GRIK1KDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113801052-B | Indolylguanidine compound containing aromatic acid ester, and preparation method and application thereof | 西安交通大学 | 2023-06-27 | — | — | CN | claimed |
| CN-113845464-B | Indolyl guanidine compound and preparation method and application thereof | 西安交通大学 | 2023-05-02 | — | — | CN | claimed |
| US-6248772-B1 | HYPOTENSIVE AGENTS; ANTIARRHYTHMIA AGENTS; ANTIDIABETIC AGENTS; ANTIPROLIFERATIVE AGENTS | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 2001-06-19 | — | — | US | claimed |
| US-6169107-B1 | USEFUL FOR THE TREATMENT AND PREVENTION OF DISEASES CAUSED BY INCREASED SODIUM/PROTON (NA.SUP.+ /H.SUP.+) EXCHANGER ACTIVITY, FOR EXAMPLE, HYPERTENSION, ARRHYTHMIA, ANGINA PECTORIS, CARDIAC HYPERTROPHY, DIABETES MELLITUS | SUMITOMO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-02 | — | — | US | claimed |
| CN-113801052-B | Indolylguanidine compound containing aromatic acid ester, and preparation method and application thereof | 西安交通大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-113801052-B | Indolylguanidine compound containing aromatic acid ester, and preparation method and application thereof | 西安交通大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-113801052-B | Indolylguanidine compound containing aromatic acid ester, and preparation method and application thereof | 西安交通大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-113845464-B | Indolyl guanidine compound and preparation method and application thereof | 西安交通大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113845464-B | Indolyl guanidine compound and preparation method and application thereof | 西安交通大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113845464-B | Indolyl guanidine compound and preparation method and application thereof | 西安交通大学 | 2023-05-02 | — | — | CN | disclosed |
| CN-113845464-A | Indolylguanidine compound and preparation method and application thereof | 西安交通大学 | 2021-12-28 | — | — | CN | disclosed |
| CN-113845464-A | Indolylguanidine compound and preparation method and application thereof | 西安交通大学 | 2021-12-28 | — | — | CN | disclosed |
| US-7985764-B2 | Amide derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2011-07-26 | — | — | US | disclosed |
| EP-1849774-B1 | CYCLOHEPTA(b)PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | TOA EIYO LTD (JP) | 2011-06-29 | — | — | EP | disclosed |
| US-7875625-B2 | 3-guanidinocarbonyl-2-methyl-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-ylmethyl hydrogen sulfate, inhibitory effect on an Na+/H+ exchanger; | TOA EIYO LTD. (JP) | 2011-01-25 | — | — | US | disclosed |
| US-20090062363-A1 | AMIDE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2009-03-05 | — | — | US | disclosed |
| US-20090012114-A1 | Cyclohepta[B]Pyridine-3-Carbonylguanidine Derivative and Pharmaceutical Product Containing Same | TOA EIYO LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1988076-A1 | AMIDE DERIVATIVE OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2008-11-05 | — | — | EP | disclosed |
| EP-1849774-A1 | CYCLOHEPTA(b)PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVE AND PHARMACEUTICAL PRODUCT CONTAINING SAME | TOA EIYO LTD. (JP) | 2007-10-31 | — | — | EP | disclosed |
| EP-0803501-B1 | Substituted guanidine derivatives and their use as Na+/H+ exchange inhibitors | SUMITOMO PHARMA (JP) | 2000-07-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062363-A1 | AMIDE DERIVATIVE OR SALT THEREOF | HTR7, HTR2B, NPSR1 | AOC3 3167/4885GRIK1 817/4885KDM4E 3397/4885 |
| US-20090012114-A1 | Cyclohepta[B]Pyridine-3-Carbonylguanidine Derivative and Pharmaceutical Product Containing Same | SLC10A6, SLC26A3, SLC9A3 | AOC3 154/4885GRIK1 1885/4885KDM4E 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.