Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 9/20 | 0.34 |
| ▸ | F3 | P13726 | 9/20 | 0.34 |
| ▸ | PLAU | P00749 | 3/20 | 0.33 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6590237 | 0.87 | F2 (0.36) | ICMTF2F3PLAUPLG | |
| SCHEMBL6591343 | 0.87 | FFAR1 (0.38) | F2PLAUPLGPLATF10 | |
| SCHEMBL6590932 | 0.86 | F10 (0.35) | F2F3PLAUPLGPLAT | |
| SCHEMBL6592628 | 0.86 | ICMT (0.36) | ICMTF2PLAUPLGPLAT | |
| SCHEMBL6596602 | 0.86 | F2 (0.37) | F2F3PLAUPLGPLAT | |
| SCHEMBL6596445 | 0.85 | PLAU (0.34) | ICMTF2F3PLAUPLG | |
| SCHEMBL6593034 | 0.85 | MRGPRX4 (0.36) | FFAR1PTGER1 | |
| SCHEMBL6592027 | 0.84 | PLAU (0.34) | ICMTF2F3PLAUPLG | |
| SCHEMBL6592361 | 0.83 | ICMT (0.38) | ICMTF2PLAUPLGPLAT | |
| SCHEMBL6592379 | 0.82 | F2 (0.34) | ICMTF2F3PLAUPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888271-B1 | BENZAMIDINE DERIVATIVES SUBSTITUTED BY AMINO ACID AND HYDROXY ACID DERIVATIVES AND THEIR USE AS ANTI-COAGULANTS | BERLEX LAB (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6242454-B1 | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants | BERLEX LABORATORIES INC. | 2001-06-05 | — | — | US | disclosed |
| US-6166088-A | CONTROLLING THROMBOSIS | BERLEX LABORATORIES, INC. (US) | 2000-12-26 | — | — | US | disclosed |
| US-6071912-A | INHIBIT HUMAN FACTOR XA AND ARE THEREFORE USEFUL AS PHARMACOLOGICAL AGENTS FOR THE TREATMENT OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY; AMINO-, OXY- AND THIA-SUBSTITUTED TRIAZINES | BERLEX LABORATORIES, INC. (US) | 2000-06-06 | — | — | US | disclosed |
| US-5994375-A | ANTICOAGULANTS | BERLEX LABORATORIES, INC. (US) | 1999-11-30 | — | — | US | disclosed |