Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA5 | P11021 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17671645 | 0.77 | HSPA5 (0.50) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL6821783 | 0.77 | TAAR1 (0.54) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL17264860 | 0.76 | HSPA5 (0.54) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL10505405 | 0.76 | HSPA5 (0.54) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL19064499 | 0.76 | HSPA5 (0.54) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL2451210 | 0.76 | APOBEC3G (0.43) | HSPA5TSHRCYP2D6TAAR1MAPT | |
| SCHEMBL14917394 | 0.76 | HSPA5 (0.48) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL14917396 | 0.76 | HSPA5 (0.48) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL14917403 | 0.76 | HSPA5 (0.43) | HSPA5TSHRHIF1ACYP2D6TAAR1 | |
| SCHEMBL14917402 | 0.76 | HSPA5 (0.43) | HSPA5TSHRHIF1ACYP2D6TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069124-B1 | 2-Benzimidazolylamine compounds as ORL1-receptor agonists | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |