Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.46 |
| ▸ | OGFRL1 | Q5TC84 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595311 | 1.00 | OPRM1 (0.54) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL6594414 | 1.00 | OPRM1 (0.54) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL6598052 | 0.99 | OPRM1 (0.52) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL6593964 | 0.83 | KCNH2 (0.52) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL1128699 | 0.82 | TP53 (0.56) | OPRM1OPRK1OPRL1OPRD1OGFRL1 | |
| SCHEMBL16128186 | 0.81 | OPRM1 (0.50) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL16127695 | 0.81 | OPRL1 (0.53) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL16128171 | 0.81 | OPRL1 (0.53) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL16127694 | 0.81 | OPRL1 (0.53) | OPRM1OPRK1OPRL1DRD2DRD4 | |
| SCHEMBL6593749 | 0.81 | OPRM1 (0.53) | OPRM1OPRK1OPRL1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069124-B1 | 2-Benzimidazolylamine compounds as ORL1-receptor agonists | PFIZER (US) | 2004-05-12 | — | — | EP | disclosed |
| US-6340681-B1 | USEFUL AS ANALGESICS IN MAMMALS | PFIZER INC | 2002-01-22 | — | — | US | disclosed |
| EP-1069124-A1 | 2-Benzimidazolylamine compounds as ORL1-receptor agonists | PFIZER INC. (US) | 2001-01-17 | — | — | EP | disclosed |