Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594571 | 1.00 | MAPT (0.71) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6593326 | 0.74 | MAPT (0.48) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6593322 | 0.74 | MAPT (0.48) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6595070 | 0.72 | RIOK2 (0.57) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6595072 | 0.72 | RIOK2 (0.57) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL23957242 | 0.71 | GRM4 (0.39) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4710302 | 0.70 | ALDH1A1 (0.58) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4710298 | 0.70 | ALDH1A1 (0.58) | MAPTKDM4ERAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3128568 | 0.66 | — | — | |
| SCHEMBL6593788 | 0.66 | TNF (0.48) | RAB9ALMNAGRM4HDAC6NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | claimed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | claimed |
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | disclosed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | disclosed |