Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | NMT1 | P30419 | 4/20 | 0.45 |
| ▸ | NMT2 | O60551 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806738 | 0.79 | MAPT (1.00) | MAPTHSP90AA1LMNAHTTSMN1; SMN2 | |
| Acetic Acid SCHEMBL7467661 | 0.79 | MAPT (0.92) | MAPTHSP90AA1LMNAHTTSMN1; SMN2 | |
| SCHEMBL22438915 | 0.70 | MEN1 (0.65) | HSP90AA1LMNAHTTPPARGMEN1 | |
| SCHEMBL11589577 | 0.70 | MEN1 (0.65) | MAPTHSP90AA1LMNAPPARGMEN1 | |
| SCHEMBL340618 | 0.69 | MAOB (0.67) | MAPTLMNAHTTSMN1; SMN2PPARG | |
| SCHEMBL1488776 | 0.69 | MEN1 (0.63) | HSP90AA1LMNAHTTPPARGMEN1 | |
| SCHEMBL4816779 | 0.69 | MEN1 (0.63) | MAPTHSP90AA1LMNAPPARGMEN1 | |
| SCHEMBL5233589 | 0.69 | MEN1 (0.63) | HSP90AA1LMNAPPARGMEN1KMT2A | |
| SCHEMBL10468397 | 0.69 | MEN1 (0.63) | HSP90AA1LMNAPPARGMEN1KMT2A | |
| SCHEMBL340106 | 0.68 | MAOB (0.69) | MAPTHSP90AA1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150952-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-10-27 | — | — | EP | disclosed |
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |