SCHEMBL340618

SCHEMBL340618

CCOC(=O)c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.67
NR4A1 P22736 1/20 0.66
NR4A2 P43354 1/20 0.66
NR4A3 Q92570 1/20 0.66
LMNA P02545 2/20 0.63
L3MBTL1 Q9Y468 1/20 0.63
PARP10 Q53GL7 1/20 0.62
SMN1; SMN2 Q16637 2/20 0.61
ALDH1A1 P00352 2/20 0.60
SRD5A2 P31213 1/20 0.60
RXRA P19793 1/20 0.60
RXRB P28702 1/20 0.60
NR1H4 Q96RI1 1/20 0.60
ADRB2 P07550 1/20 0.60
ADRB1 P08588 1/20 0.60
ADRB3 P13945 1/20 0.60
HDAC3 O15379 1/20 0.58
HDAC1 Q13547 1/20 0.58
HDAC2 Q92769 1/20 0.58
NCOR2 Q9Y618 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL977234 0.96 SRD5A2 (0.68) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL11602002 0.94 SMN1; SMN2 (0.61) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL978523 0.93 MAOB (0.58) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL50807 0.89 KMT2A (0.73) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL977023 0.88 MAOB (0.53) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL20830918 0.88 KMT2A (0.67) MAOBNR4A1NR4A2NR4A3LMNA
SCHEMBL4058623 0.88 MAOB (0.69) MAOBLMNAL3MBTL1PARP10SMN1; SMN2
SCHEMBL11601531 0.88 MAOB (0.69) MAOBLMNAL3MBTL1PARP10SMN1; SMN2
SCHEMBL11255125 0.87 MAPT (0.64) LMNAL3MBTL1SMN1; SMN2ALDH1A1ADRB2
SCHEMBL7370844 0.87 SMN1; SMN2 (0.55) MAOBNR4A1NR4A2NR4A3LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12097629-B2 Razor cartridge BIC Violex Single Member S.A. (GR) 2024-09-24 US disclosed
US-11919183-B2 Razor cartridge BIC Violex Single Member S.A. (GR) 2024-03-05 US disclosed
US-20240009874-A1 RAZOR CARTRIDGE BIC Violex Single Member S.A. (GR) 2024-01-11 US disclosed
EP-3815861-B1 RAZOR CARTRIDGE BIC VIOLEX SINGLE MEMBER SA (GR) 2022-08-10 EP disclosed
US-20220009114-A1 RAZOR CARTRIDGE BIC VIOLEX S.A. (GR) 2022-01-13 US disclosed
EP-3887102-A2 RAZOR CARTRIDGE BIC-Violex S.A. (GR) 2021-10-06 EP disclosed
EP-3815861-A1 RAZOR CARTRIDGE BIC Violex S.A. (GR) 2021-05-05 EP disclosed
EP-3112348-A1 SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES Tairx, Inc. (TW) 2017-01-04 EP disclosed
EP-2593435-B1 SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES TAIRX INC (TW) 2016-09-07 EP disclosed
CN-103347859-B Synthesis and Anticancer Activity of Aryl and Heteroaryl Quinoline Derivatives EFFICIENT PHARMA MANAGEMENT CORP. (CN) 2015-12-02 CN disclosed
EP-1087977-A1 THIENODIPYRIDINE DERIVATIVES, PRODUCTION AND USE THEREOF Takeda Chemical Industries, Ltd. (JP) 2001-04-04 EP disclosed
WO-1999065916-A1 THIENODIPYRIDINE DERIVATIVES, PRODUCTION AND USE THEREOF TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-12-23 WO disclosed
EP-0320032-B1 Pyridizinamine derivatives JANSSEN PHARMACEUTICA NV (BE) 1995-01-18 EP disclosed
US-5231184-A Viricide intermediate JANSSEN PHARMACEUTICA N.V. (BE) 1993-07-27 US disclosed
US-5106973-A Viricide intermediates JANSSEN PHARMACEUTICA N.V. (BE) 1992-04-21 US disclosed
US-4992433-A Viricides JANSSEN PHARMACEUTICA N.V. (BE) 1991-02-12 US disclosed
EP-0320032-A1 Pyridizinamine derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1989-06-14 EP disclosed
CN-1033274-A The preparation method of new Pyridazinyl amine derivative JANSSEN PHARMACEUTICA NV (BE) 1989-06-07 CN disclosed
US-4545984-A TOPICAL TREATMENT OF OILY HAIR HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 1985-10-08 US disclosed
US-4098816-A HYPOGLYCEMIC AGENTS AND ANTILIPEMIC AGENTS BEECHAM GROUP LIMITED (GB) 1978-07-04 US disclosed