Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9495233 | 0.81 | GRM5 (0.47) | GRM5 | |
| SCHEMBL9499428 | 0.78 | MCHR1 (0.48) | GRM5FFAR1FFAR4 | |
| SCHEMBL9497080 | 0.78 | MCHR1 (0.52) | GRM5APP | |
| SCHEMBL3955825 | 0.77 | GRM5 (0.54) | GRM5FFAR1FFAR4APP | |
| SCHEMBL10131002 | 0.77 | GRM5 (0.54) | GRM5FFAR1FFAR4APP | |
| SCHEMBL30833070 | 0.77 | GRM5 (0.54) | GRM5FFAR1FFAR4APP | |
| SCHEMBL10131003 | 0.77 | GRM5 (0.54) | GRM5FFAR1FFAR4APPGRM4 | |
| SCHEMBL10131004 | 0.77 | GRM5 (0.54) | GRM5FFAR1FFAR4APPGRM4 | |
| SCHEMBL9495546 | 0.76 | ACACB (0.53) | — | |
| Hydrochloric Acid SCHEMBL4309309 | 0.76 | GRM5 (0.53) | GRM5FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157025-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2004-03-10 | — | — | EP | disclosed |
| US-6498166-B1 | POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2; TREATING PAIN, FEVER AND INFLAMMATION | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1157025-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000052008-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |