Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594699 | 0.88 | MAPK14 (0.68) | MAPK14PTGS2PTGS1CA1CA2 | |
| SCHEMBL5377634 | 0.87 | PTGS2 (0.53) | MAPK14PTGS2PTGS1PDPK1CA1 | |
| SCHEMBL6592574 | 0.87 | MAPK14 (0.53) | MAPK14PTGS2PTGS1CA1CA2 | |
| SCHEMBL5366953 | 0.85 | MAPK14 (0.54) | MAPK14PTGS2PTGS1PDPK1 | |
| SCHEMBL5373881 | 0.82 | PTGS2 (0.52) | MAPK14PTGS2PTGS1CA1CA2 | |
| SCHEMBL7841227 | 0.82 | MAPK14 (0.60) | MAPK14PTGS2PTGS1CA1CA2 | |
| SCHEMBL5371166 | 0.77 | PTGS2 (0.66) | MAPK14PTGS2PTGS1 | |
| SCHEMBL6591824 | 0.76 | PTGS2 (0.63) | MAPK14PTGS2PTGS1MAPTCA1 | |
| SCHEMBL5373901 | 0.75 | PTGS2 (0.59) | MAPK14PTGS2PTGS1 | |
| SCHEMBL6808976 | 0.75 | CA12 (0.54) | PTGS2PTGS1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157025-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2004-03-10 | — | — | EP | claimed |
| US-6498166-B1 | POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2; TREATING PAIN, FEVER AND INFLAMMATION | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | claimed |
| JP-2002538157-A | — | — | 2002-11-12 | — | — | JP | claimed |
| EP-1157025-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2001-11-28 | — | — | EP | claimed |
| WO-2000052008-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2000-09-08 | — | — | WO | claimed |
| EP-1157025-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2004-03-10 | — | — | EP | disclosed |
| US-6498166-B1 | POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2; TREATING PAIN, FEVER AND INFLAMMATION | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1157025-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000052008-A1 | PYRAZOLOPYRIDINES | GLAXO GROUP LIMITED (GB) | 2000-09-08 | — | — | WO | disclosed |