Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 17/20 | 0.73 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.55 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600760 | 0.88 | CCR2 (0.79) | CCR2 | |
| SCHEMBL6598061 | 0.88 | CCR2 (0.79) | CCR2 | |
| SCHEMBL7008246 | 0.86 | CCR2 (0.81) | CCR2PLA2G10GPR35 | |
| SCHEMBL3209668 | 0.85 | CCR2 (0.74) | CCR2 | |
| SCHEMBL3961949 | 0.85 | CCR2 (1.00) | CCR2GPR35 | |
| SCHEMBL5378162 | 0.84 | CCR2 (1.00) | CCR2PLA2G10GPR35 | |
| SCHEMBL27811964 | 0.84 | CCR2 (0.76) | CCR2PLA2G10GPR35 | |
| SCHEMBL6300906 | 0.81 | CCR2 (1.00) | CCR2 | |
| SCHEMBL3957310 | 0.81 | CCR2 (1.00) | CCR2PLA2G10GPR35 | |
| SCHEMBL3969276 | 0.81 | CCR2 (0.82) | CCR2PLA2G10GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150954-B1 | ANTI-IMFLAMMATORY INDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-10-13 | — | — | EP | disclosed |
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | disclosed |