Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.78 |
| ▸ | POLB | P06746 | 2/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.78 |
| ▸ | GAA | P10253 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | APP | P05067 | 10/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.52 |
| ▸ | MMP9 | P14780 | 2/20 | 0.52 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.52 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.52 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595479 | 1.00 | KDM4E (0.81) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595936 | 0.90 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595939 | 0.90 | ALDH1A1 (1.00) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595926 | 0.88 | MAPT (1.00) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595922 | 0.88 | MAPT (1.00) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6594343 | 0.87 | MAPT (0.80) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6594347 | 0.87 | MAPT (0.80) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595735 | 0.84 | KDM4E (0.81) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6595740 | 0.84 | KDM4E (0.81) | KDM4EALDH1A1MAPTMEN1POLB | |
| SCHEMBL6592764 | 0.84 | ALDH1A1 (0.83) | KDM4EALDH1A1MAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | claimed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | claimed |
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | disclosed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | disclosed |