Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.55 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 4/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.51 |
| ▸ | TDO2 | P48775 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.51 |
| ▸ | CASP6 | P55212 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27415734 | 0.82 | TDP1 (0.67) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL11819002 | 0.81 | TDP1 (0.64) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL9836130 | 0.79 | TDP1 (0.62) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL619830 | 0.79 | TDP1 (0.62) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL10549357 | 0.79 | TDP1 (0.62) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL2379102 | 0.79 | TDP1 (0.62) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL27932601 | 0.79 | TDP1 (0.62) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL57166 | 0.79 | TDP1 (1.00) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL29475175 | 0.79 | TDP1 (1.00) | TDP1POLBNCOA1NCOA3CTSB | |
| SCHEMBL5659170 | 0.79 | TDP1 (0.56) | TDP1POLBNCOA1NCOA3CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373252-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | Aventis Pharma S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002076975-A1 | CHEMICAL DERIVATIVES AND THEIR USE AS ANTI-TELOMERASE AGENT | AVENTIS PHARMA S.A. (FR) | 2002-10-03 | — | — | WO | disclosed |