Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395612 | 0.86 | ALDH1A1 (0.72) | ALDH1A1POLBMEN1HTTKMT2A | |
| SCHEMBL4028724 | 0.79 | ALDH1A1 (0.61) | ALDH1A1HTTSIGMAR1TSHRGAA | |
| SCHEMBL25281969 | 0.78 | ALDH1A1 (0.59) | ALDH1A1PRMT1MEN1HTTKMT2A | |
| SCHEMBL18221849 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MEN1HTTKMT2ATSHR | |
| SCHEMBL12640166 | 0.78 | ALDH1A1 (1.00) | ALDH1A1MEN1HTTKMT2ATSHR | |
| SCHEMBL1395602 | 0.78 | ALDH1A1 (0.79) | ALDH1A1MEN1HTTKMT2AGAA | |
| SCHEMBL15522663 | 0.77 | ALDH1A1 (0.62) | ALDH1A1POLBMEN1HTTKMT2A | |
| SCHEMBL6104693 | 0.77 | ALDH1A1 (0.58) | ALDH1A1POLBMEN1HTTKMT2A | |
| SCHEMBL15581459 | 0.77 | ALDH1A1 (0.62) | ALDH1A1MEN1HTTKMT2ASIGMAR1 | |
| SCHEMBL4773112 | 0.76 | ALDH1A1 (0.52) | ALDH1A1POLBTAAR1HSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |