Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.58 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | BCR | P11274 | 3/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4496561 | 0.99 | SRC (0.57) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL4493118 | 0.97 | SRC (0.59) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL4497195 | 0.92 | EGFR (0.57) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL5723525 | 0.92 | SRC (0.62) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL4489309 | 0.91 | EGFR (0.58) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL4498596 | 0.87 | SRC (0.55) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL7130437 | 0.87 | SRC (0.54) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL4489459 | 0.87 | SRC (0.56) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL5724110 | 0.86 | SRC (0.54) | SRCEGFRERBB2ABL1BCR | |
| SCHEMBL5723587 | 0.86 | SRC (0.68) | SRCEGFRERBB2ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1409481-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | Astrazeneca AB (SE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |
| WO-2003008409-A1 | QUINOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2003-01-30 | — | — | WO | disclosed |