Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 18/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | BCR | P11274 | 4/20 | 0.53 |
| ▸ | FYN | P06241 | 4/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.52 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | STK25 | O00506 | 1/20 | 0.51 |
| ▸ | CIT | O14578 | 1/20 | 0.51 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.51 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | CASK | O14936 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.51 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.51 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.51 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493118 | 0.88 | SRC (0.59) | SRCKDRABL1BCRFYN | |
| SCHEMBL6596134 | 0.87 | SRC (0.58) | SRCKDRABL1BCRFYN | |
| SCHEMBL4497195 | 0.87 | EGFR (0.57) | SRCKDRABL1BCRFYN | |
| SCHEMBL5723525 | 0.87 | SRC (0.62) | SRCKDRABL1BCREGFR | |
| Hydrochloric Acid SCHEMBL4496561 | 0.86 | SRC (0.57) | SRCKDRABL1BCRFYN | |
| SCHEMBL5723587 | 0.86 | SRC (0.68) | SRCKDRABL1BCRFYN | |
| SCHEMBL4489309 | 0.86 | EGFR (0.58) | SRCKDRABL1BCRMAP2K1 | |
| SCHEMBL4489459 | 0.84 | SRC (0.56) | SRCABL1BCRMAP2K1ABL2 | |
| SCHEMBL7128327 | 0.84 | SRC (0.58) | SRCKDRABL1BCRFYN | |
| SCHEMBL5724110 | 0.82 | SRC (0.54) | SRCABL1BCRMAP2K1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | claimed |
| WO-2003047582-A1 | QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS | ASTRAZENECA AB (SE) | 2003-06-12 | — | — | WO | disclosed |