Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.53 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP10 | P09238 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | MMP15 | P51511 | 1/20 | 0.47 |
| ▸ | ADAMTS1 | Q9UHI8 | 1/20 | 0.47 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6596668 | 0.86 | ADAM17 (0.53) | ADAM17MMP13 | |
| SCHEMBL6643952 | 0.82 | ADAM17 (0.46) | ADAM17MMP13 | |
| SCHEMBL6596319 | 0.81 | ADAM17 (0.71) | ADAM17MMP13 | |
| SCHEMBL6597717 | 0.78 | ADAM17 (0.67) | ADAM17MMP13ADAMTS4MMP3MMP10 | |
| Trifluoroacetic Acid SCHEMBL6599036 | 0.77 | ADAM17 (0.63) | ADAM17MMP13ADAMTS4MMP3MMP10 | |
| SCHEMBL7691196 | 0.75 | ADAM17 (0.52) | ADAM17MMP13 | |
| SCHEMBL6696849 | 0.70 | ADAM17 (0.89) | ADAM17MMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL6592612 | 0.70 | ADAM17 (0.82) | ADAM17MMP13ADAMTS4MMP3MMP10 | |
| SCHEMBL6596874 | 0.69 | ADAM17 (1.00) | ADAM17MMP13ADAMTS4MMP3MMP8 | |
| SCHEMBL6597098 | 0.69 | ADAM17 (0.89) | ADAM17MMP13ADAMTS4MMP3MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263756-B1 | BETA-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-ALPHA | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2004-02-25 | — | — | EP | claimed |