Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27534151 | 0.83 | CDC7 (0.54) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL6595714 | 0.82 | CDK2 (0.52) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL6596886 | 0.81 | DYRK3 (0.40) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL4024077 | 0.78 | CDK2 (0.46) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL6105497 | 0.77 | CDK2 (0.51) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL4030274 | 0.76 | CDK2 (0.54) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL1448411 | 0.74 | CDK2 (0.50) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL4024211 | 0.73 | CCNT1 (0.48) | DYRK1ACCNT1CDK9DYRK3DYRK2 | |
| SCHEMBL6706964 | 0.72 | CDK2 (0.67) | CCNT1CDK9CDK2CDK4CDK5 | |
| SCHEMBL26544453 | 0.72 | ALDH1A1 (0.46) | TDP1ALDH1A1LMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |