Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.45 |
| ▸ | CDK9 | P50750 | 2/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.45 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448021 | 0.81 | CDC7 (0.46) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL6105497 | 0.80 | CDK2 (0.51) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL6595871 | 0.76 | DYRK1A (0.45) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL6595694 | 0.75 | DYRK1A (0.44) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL5109523 | 0.74 | KDR (0.53) | DYRK1ACCNT1CDK9CDK2CDK5 | |
| SCHEMBL278830 | 0.73 | CDK2 (0.56) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL1447697 | 0.71 | CDC7 (0.46) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL5109260 | 0.70 | MAPK14 (0.49) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL4031036 | 0.70 | CDK2 (0.45) | DYRK1ADYRK3CCNT1CDK9DYRK2 | |
| SCHEMBL22692182 | 0.70 | LMNA (0.45) | KDM4EALDH1A1MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |